Publications (2012-)

Fukaya R, Maglione M, Sigrist SJ, Sakaba T. (2021) Rapid Ca2+ channel accumulation contributes to cAMP-mediated increase in transmission at hippocampal mossy fiber synapses. Proc Natl Acad Sci U S A 118: e2016754118.

Miki T, Midorikawa M, Sakaba T. (2020) Direct imaging of rapid tethering of synaptic vesicles accompanying exocytosis at a fast central synapse. Proc Natl Acad Sci U S A 117: 14493-14502.

Malagon G, Miki T, Tran V, Gomez L, Marty A. (2020) Incomplete vesicular docking limits synaptic strength under high release probability conditions. eLife 9: e52137.

Jäpel M, Gerth F, Sakaba T, Bacetic J, Yao L, Koo SJ, Maritzen T, Freund C, Haucke V. (2020) Intersectin-Mediated Clearance of SNARE Complexes Is Required for Fast Neurotransmission. Cell Rep. 30(2): 409-420.

Miyano R, Miki T, Sakaba T. (2019) Ca-dependence of synaptic vesicle exocytosis and endocytosis at the hippocampal mossy fibre terminal. J Physiol. 597(16): 4373-4386.

Miki T. (2019) What we can learn from cumulative numbers of vesicular release events. Front. Cell Neurosci. 13: 257.

Kitagawa M, Sakaba T. (2019) Developmental changes in the excitatory short-term plasticity at input synapses in the rat inferior colliculus. Eur. J. Neurosci. 50(5): 2830-2846.


Sakaba T. (2018) Optimal dissection of a model circuit. J Physiol. 596(20): 4807-4808.


Edamatsu M, Miyano R, Fujikawa A, Fujii F, Hori T, Sakaba T, Oohashi T. (2018) Hapln4/Bral2 is a selective regulator for formation and transmission of GABAergic synapses between Purkinje and deep cerebellar nuclei neurons. J Neurochem. 147(6):748-763. 

Hashimotodani Y, Karube F, Yanagawa Y, Fujiyama F, Kano M. (2018) Supramammillary nucleus afferents to the dentate gyrus co-release glutamate and GABA and potentiate granule cell output. Cell Rep. 25: 2704-2715.

Miki T, Nakamura Y, Malagon G, Neher E, Marty A. (2018) Two-component latency distributions indicate two-step vesicular release at simple glutamatergic synapses. Nat Commun 9: 3943.

Sakaba T. (2018) Kinetics of transmitter release at the calyx of Held synapse. Proc Jpn Acad Ser B Phys Biol Sci. 2018;94(3):139-152.

Kawaguchi SY, Sakaba T. (2017) Fast Ca2+ Buffer-Dependent Reliable but Plastic Transmission at Small CNS Synapses Revealed by Direct Bouton Recording. Cell Rep 21: 3338-3345. 

Midorikawa M, Sakaba T (2017) Kinetics of Releasable Synaptic Vesicles and Their Plastic Changes at Hippocampal Mossy Fiber Synapses. Neuron 96: 1033-1040.

Miki T, Kaufmann WA, Malagon G, Gomez L, Tabuchi K, Watanabe M, Shigemoto R, Marty A (2017) Numbers of presynaptic Ca2+ channel clusters match those of functionally defined vesicular docking sites in single central synapses. Proc Natl Acad Sci U S A 114: E5246-E5255.

Soykan T, Kaempf N, Sakaba T, Vollweiter D, Goerdeler F, Puchkov D, Kononenko NL, Haucke V (2017) Synaptic Vesicle Endocytosis Occurs on Multiple Timescales and Is Mediated by Formin-Dependent Actin Assembly. Neuron 93: 854-866.

Miki T, Malagon G, Pulido C, Llano I, Neher E, Marty A (2016) Actin- and Myosin-Dependent Vesicle Loading of Presynaptic Docking Sites Prior to Exocytosis. Neuron 91: 808-823. 

Okamoto Y, Lipstein N, Hua Y, Lin KH, Brose N, Sakaba T, Midorikawa M (2016) Distinct modes of endocytotic presynaptic membrane and protein uptake at the calyx of Held terminal of rats and mice. eLife 5: e14643.

Malagon G, Miki T, Llano I, Neher E, Marty A (2016) Counting Vesicular Release Events Reveals Binomial Release Statistics at Single Glutamatergic Synapses. J Neurosci 36: 4010-25.

Midorikawa M, Sakaba T (2015) Imaging Exocytosis of Single Synaptic Vesicles at a Fast CNS Presynaptic Terminal. Neuron 88: 492-498.

Díaz-Rojas F, Sakaba T, Kawaguchi SY (2015) Ca2+ current facilitation determines short-term facilitation at inhibitory synapses between cerebellar Purkinje cells. J Physiol 593: 4889-904.

Kawaguchi SY, Sakaba T (2015) Control of Inhibitory Synaptic Outputs by Low Excitability of Axon Terminals Revealed by Direct Recording. Neuron 85: 1273-1288.

Midorikawa M, Okamoto Y, Sakaba T (2014) Developmental changes in Ca2+ channel subtypes regulating endocytosis at the calyx of Held. J Physiol 592: 3495-510.

Lipstein N*, Sakaba T*, Cooper BH, Lin KH, Strenzke N, Ashery U, Rhee JS, Taschenberger H, Neher E, Brose N (2013) Dynamic Control of Synaptic Vesicle Replenishment and Short-Term Plasticity by Ca2+-Calmodluin-Munc13-1 Signalling. Neuron 79: 82-96 (* equal contribution).

Sakaba T, Kononenko NL, Bacetic J, Pechstein A, Schmoranzer J, Yao L, Barth H, Shupliakov O, Kobler O, Aktories A, Haucke V (2013) Fast neurotransmitter release regulated by the endocytotic scaffold intersectin. Proc Natl Acad Sci U S A 110: 8266-8271.

Trigo FF, Sakaba T, Ogden D, Marty A (2012) Readily releasable pool of synaptic vesicles measured at single synaptic contacts. Proc Natl Acad Sci U S A 109: 18138-18143.

Yao L, Sakaba T (2012) Activity-dependent modulation of endocytosis by calmodulin at a large central synapse. Proc Natl Acad Sci U S A 109: 291-296.

Selected Publications (-2011)

Hosoi N, Holt M, Sakaba T (2009) Calcium-Dependent Exo- and Endocytotic Coupling at a Glutamatergic Synapse. Neuron 62: 216-229.


Neher E, Sakaba T (2008) Multiple Roles of Calcium Ions in the Regulation of Neurotransmitter Release. Neuron 59: 861-872 (review).


Sakaba T (2008) Two Ca2+-Dependent Steps Controlling Synaptic Vesicle Fusion and Replenishment at the Cerebellar Basket Cell Terminal. Neuron 57: 406-419.


Wadel K, Neher E, Sakaba T (2007) The coupling between synaptic vesicles and Ca2+ channels determines fast neurotransmitter release. Neuron 53: 563-575.


Sakaba T (2006) Roles of the fast- and the slowly-releasing vesicles in synaptic transmission at the calyx of Held. J Neurosci 26: 5863-5871.


Sakaba T, Stein A, Jahn R, Neher E (2005) Distinct kinetic changes in neurotransmitter release after SNARE protein cleavage. Science 309: 491-494.


Sakaba T, Neher E (2003) Direct modulation of glutamatergic synaptic vesicle priming by GABAB receptor activation. Nature 424: 775-778.


Sakaba T, Neher E (2001) Calmodulin mediates rapid recruitment of fast-releasing synaptic vesicles at a calyx-type synapse. Neuron 32: 1119-1131.


Sakaba T, Neher E (2001) Quantitative relationship between transmitter release and calcium current at the calyx of Held synapse. J Neurosci 21: 462-476.


Neher E, Sakaba T (2001) Combining deconvolution and noise analysis for the estimation of transmitter release rates at the calyx of Held. J Neurosci 21: 444-461.


von Gersdorff H, Sakaba T, Berglund K, Tachibana M (1998) Submillisecond kinetics of glutamate release from a sensory synapse. Neuron 21: 1177-1188.