SAKABA LAB

Fukaya R, Hirai H, Sakamoto H, Hashimotodani Y, Hirose K, Sakaba T. (2023) Increased vesicle fusion competence underlies long -term potentiation at hippocampal mossy fiber synapses. Science Advances, 22;9(8):eadd3616.

 

Hirai H, Sakaba T, Hashimotodani Y. (2022) Subcortical glutamatergic inputs exhibit a Hebbian form of long-term potentiation in the dentate gyrus. Cell Reports, 41, 111871.

 

Tabuchi E, Sakaba T, Hashimotodani Y. (2022) Excitatory selective LTP of supramammillary glutamatergic/GABAergic cotransmission potentiates dentate granule cell firing. Proc Natl Acad Sci U S A 119: e2119636119.

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Tran V, Miki T, Marty A. (2022) Three small vesicular pools in sequence govern synaptic response dynamics during action potential trains. Proc Natl Acad Sci U S A 119: e2114469119.

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Tanaka M, Sakaba T, Miki T. (2021) Quantal analysis estimates docking site occupancy determining short-term depression at hippocampal glutamatergic synapses. J Physiol 599: 5301-5327.

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Fukaya R, Maglione M, Sigrist SJ, Sakaba T. (2021) Rapid Ca2+ channel accumulation contributes to cAMP-mediated increase in transmission at hippocampal mossy fiber synapses. Proc Natl Acad Sci U S A 118: e2016754118.

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Miki T, Midorikawa M, Sakaba T. (2020) Direct imaging of rapid tethering of synaptic vesicles accompanying exocytosis at a fast central synapse. Proc Natl Acad Sci U S A 117: 14493-14502.

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Malagon G, Miki T, Tran V, Gomez L, Marty A. (2020) Incomplete vesicular docking limits synaptic strength under high release probability conditions. eLife 9: e52137.

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Jäpel M, Gerth F, Sakaba T, Bacetic J, Yao L, Koo SJ, Maritzen T, Freund C, Haucke V. (2020) Intersectin-Mediated Clearance of SNARE Complexes Is Required for Fast Neurotransmission. Cell Rep. 30(2): 409-420.

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Miyano R, Miki T, Sakaba T. (2019) Ca-dependence of synaptic vesicle exocytosis and endocytosis at the hippocampal mossy fibre terminal. J Physiol. 597(16): 4373-4386.

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Miki T. (2019) What we can learn from cumulative numbers of vesicular release events. Front. Cell Neurosci. 13: 257.

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Kitagawa M, Sakaba T. (2019) Developmental changes in the excitatory short-term plasticity at input synapses in the rat inferior colliculus. Eur. J. Neurosci. 50(5): 2830-2846.

 

Sakaba T. (2018) Optimal dissection of a model circuit. J Physiol. 596(20): 4807-4808.

 

Edamatsu M, Miyano R, Fujikawa A, Fujii F, Hori T, Sakaba T, Oohashi T. (2018) Hapln4/Bral2 is a selective regulator for formation and transmission of GABAergic synapses between Purkinje and deep cerebellar nuclei neurons. J Neurochem. 147(6):748-763. 

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Hashimotodani Y, Karube F, Yanagawa Y, Fujiyama F, Kano M. (2018) Supramammillary nucleus afferents to the dentate gyrus co-release glutamate and GABA and potentiate granule cell output. Cell Rep. 25: 2704-2715.

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Miki T, Nakamura Y, Malagon G, Neher E, Marty A. (2018) Two-component latency distributions indicate two-step vesicular release at simple glutamatergic synapses. Nat Commun 9: 3943.

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Sakaba T. (2018) Kinetics of transmitter release at the calyx of Held synapse. Proc Jpn Acad Ser B Phys Biol Sci. 2018;94(3):139-152.

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Kawaguchi SY, Sakaba T. (2017) Fast Ca2+ Buffer-Dependent Reliable but Plastic Transmission at Small CNS Synapses Revealed by Direct Bouton Recording. Cell Rep 21: 3338-3345. 

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Midorikawa M, Sakaba T (2017) Kinetics of Releasable Synaptic Vesicles and Their Plastic Changes at Hippocampal Mossy Fiber Synapses. Neuron 96: 1033-1040.

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Miki T, Kaufmann WA, Malagon G, Gomez L, Tabuchi K, Watanabe M, Shigemoto R, Marty A (2017) Numbers of presynaptic Ca2+ channel clusters match those of functionally defined vesicular docking sites in single central synapses. Proc Natl Acad Sci U S A 114: E5246-E5255.

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Soykan T, Kaempf N, Sakaba T, Vollweiter D, Goerdeler F, Puchkov D, Kononenko NL, Haucke V (2017) Synaptic Vesicle Endocytosis Occurs on Multiple Timescales and Is Mediated by Formin-Dependent Actin Assembly. Neuron 93: 854-866.

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Miki T, Malagon G, Pulido C, Llano I, Neher E, Marty A (2016) Actin- and Myosin-Dependent Vesicle Loading of Presynaptic Docking Sites Prior to Exocytosis. Neuron 91: 808-823. 

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Okamoto Y, Lipstein N, Hua Y, Lin KH, Brose N, Sakaba T, Midorikawa M (2016) Distinct modes of endocytotic presynaptic membrane and protein uptake at the calyx of Held terminal of rats and mice. eLife 5: e14643.

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Malagon G, Miki T, Llano I, Neher E, Marty A (2016) Counting Vesicular Release Events Reveals Binomial Release Statistics at Single Glutamatergic Synapses. J Neurosci 36: 4010-25.

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Midorikawa M, Sakaba T (2015) Imaging Exocytosis of Single Synaptic Vesicles at a Fast CNS Presynaptic Terminal. Neuron 88: 492-498.

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Díaz-Rojas F, Sakaba T, Kawaguchi SY (2015) Ca2+ current facilitation determines short-term facilitation at inhibitory synapses between cerebellar Purkinje cells. J Physiol 593: 4889-904.

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Kawaguchi SY, Sakaba T (2015) Control of Inhibitory Synaptic Outputs by Low Excitability of Axon Terminals Revealed by Direct Recording. Neuron 85: 1273-1288.

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Midorikawa M, Okamoto Y, Sakaba T (2014) Developmental changes in Ca2+ channel subtypes regulating endocytosis at the calyx of Held. J Physiol 592: 3495-510.

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Lipstein N*, Sakaba T*, Cooper BH, Lin KH, Strenzke N, Ashery U, Rhee JS, Taschenberger H, Neher E, Brose N (2013) Dynamic Control of Synaptic Vesicle Replenishment and Short-Term Plasticity by Ca2+-Calmodluin-Munc13-1 Signalling. Neuron 79: 82-96 (* equal contribution).

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Sakaba T, Kononenko NL, Bacetic J, Pechstein A, Schmoranzer J, Yao L, Barth H, Shupliakov O, Kobler O, Aktories A, Haucke V (2013) Fast neurotransmitter release regulated by the endocytotic scaffold intersectin. Proc Natl Acad Sci U S A 110: 8266-8271.

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Trigo FF, Sakaba T, Ogden D, Marty A (2012) Readily releasable pool of synaptic vesicles measured at single synaptic contacts. Proc Natl Acad Sci U S A 109: 18138-18143.

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Yao L, Sakaba T (2012) Activity-dependent modulation of endocytosis by calmodulin at a large central synapse. Proc Natl Acad Sci U S A 109: 291-296.